Sex Determination in Drosophila: Chromosomes, Genic Balance Theory & X/A Ratio

Drosophila is a type of fly belonging to the family Drosophilidae. These flies are commonly referred to as “small fruit flies,” “pomace flies,” “vinegar flies,” or “wine flies,” as many species tend to hover around ripe or decaying fruits and vegetables.

The term Drosophila is derived from two Greek words: “δρόσος” (drósos), meaning “dew,” and “φιλία” (philía), meaning “love.” Thus, Drosophila translates to “dew lover.”

Drosophila flies serve as essential model organisms in genetic studies, including research on eye development, complex diseases, human disorders, genetic influences on behavior, chromosomal structures, mutations, and sex determination.

Drosophila male and female chromosomes diagram illustrating sex determination.
Graphical representation of the X/A ratio in Drosophila sex determination.
Comparison of Drosophila intersex, meta female, and meta male based on chromosome ratios.

Sex Determination in Drosophila

Common Name Fruit Fly, Vinegar Fly
Scientific Classification
  • Domain: Eukaryota
  • Kingdom: Animalia
  • Phylum: Arthropoda
  • Class: Insecta
  • Order: Diptera
  • Family: Drosophilidae
  • Genus: Drosophila
Chromosome Number 8 (4 pairs: 3 autosomes + 1 sex chromosome pair)
Model Organism Used in genetics, mutations, disease research, behavior studies
Sex Determination System Sex Index Ratio (X/A Ratio)
Sex Determination Based on Ratio
  • X/A = 1 → Female
  • X/A = 0.5 → Male
  • 0.5 < X/A < 1 → Intersex (Sterile)
  • X/A > 1 → Super Female / Meta Female
  • X/A < 0.5 → Super Male / Meta Male
Origin of Name Greek: “δρόσος” (drósos) = Dew, “φιλία” (philía) = Love → “Dew Lover”
Significance in Genetics
  • First used in genetic research by Thomas Hunt Morgan
  • Helped discover sex-linked inheritance
  • Used in chromosomal studies and mutation research
Habitat Common around ripe and decaying fruits, vegetables, and fermented substances

Drosophila possesses 8 chromosomes. In 1922,0 Calvin Bridges proposed the Genic Balance Theory to explain sex determination in Drosophila. According to this theory, sex determination is governed by the Sex Index Ratio, and the Y chromosome plays no role in the process.

Diagram showing the X/A sex determination ratio in Drosophila. Comparison chart of Drosophila male, female, intersex, and meta forms based on X/A ratio. Illustration of Drosophila chromosomes and their role in sex determination. Flowchart explaining the Genic Balance Theory in Drosophila genetics. Microscopic image of Drosophila chromosomes used in genetic studies.

The sex index ratio is determined based on the number of X chromosomes and the pairs of autosomal chromosomes (A).

Sex Index Ratio = Number of X Chromosomes​ / Pairs of Autosomal Chromosomes (A)

This ratio controls sex determination in Drosophila.

For Drosophila, the sex index ratio functions as follows:

  • The ratio of X chromosomes to autosomes (X/A) determines the organism’s sex.
  • Sex Index Ratio = 1 → Results in a Female.
  • Sex Index Ratio = 0.5 → Results in a Male.
  • Sex Index Ratio between 0.5 and 1 (e.g., 0.6, 0.7, 0.8, 0.9) → Results in Intersex, which is Sterile.
  • Sex Index Ratio > 1 (e.g., 2, 3, 4, 7, 8, etc.) → Results in Super Female / Meta Female.
  • Sex Index Ratio < 0.5 (e.g., 0.4, 0.3, 0.2, 0.1, etc.) → Results in Super Male / Meta Male.
Sex Determination in Drosophila: Chromosomes, Genic Balance Theory & X/A Ratio
Sex Index Ratio Sex
1 Female
0.5 Male
0.6, 0.7, 0.8, 0.9 InterSex
Greater than 1 (2, 3, 4, 7, 8…) Super Female / Meta Female
Less than 0.5 (0.4, 0.3, 0.2, 0.1…) Super Male / Meta Male

Note:

  • If the sex index ratio is 0.5, the individual will be a normal male.
  • If the ratio is less than 0.5, the individual will be a Super Male / Meta Male.
  • If the sex index ratio is 1, the individual will be a normal female.
  • If the ratio is greater than 1, the individual will be a Super Female / Meta Female.
  • If the sex index ratio falls between 0.5 and 1, the individual will be intersex, which is sterile.
Sex Determination in Drosophila: Understanding the X/A Ratio

Learn how sex determination in Drosophila is regulated by the Sex Index Ratio (X/A Ratio). Understand chromosome numbers, genic balance theory, and key research findings in fruit fly genetics.

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People Also Ask?

What is the Sex Index Ratio for sex determination in Drosophila?
The Sex Index Ratio is determined based on the number of X-chromosomes and the pairs of autosomal chromosomes (A).
What is the formula for the Sex Index Ratio?
Sex Index Ratio = Number of X-chromosomes / Pairs of autosomal chromosomes (A)
What sex is produced when the Sex Index Ratio is 1?
A female is produced when the Sex Index Ratio is 1.
What does a Sex Index Ratio = 0.5 mean?
A Sex Index Ratio = 0.5 results in a male.
What sex is produced when the Sex Index Ratio is between 0.5 and 1?
An intersex individual is produced, which is sterile.
What sex is produced when the Sex Index Ratio is greater than 1?
A Super Female / Meta Female is produced.
What sex is produced when the Sex Index Ratio is less than 0.5?
A Super Male / Meta Male is produced.
What is the classification of an organism with a Sex Index Ratio between 0.6 and 0.9?
An organism with a Sex Index Ratio between 0.6 and 0.9 is classified as intersex, which is sterile.
If Drosophila has 6 X-chromosomes and 4 autosomal chromosomes (A), what is the sex?
Sex Index Ratio = 6 / (4/2) = 3. Since it is greater than 1, the organism is a Super Female / Meta Female.
If Drosophila has 2 X-chromosomes and 6 autosomal chromosomes (A), what is the sex?
Sex Index Ratio = 2 / (6/2) = 0.67. Since it is between 0.5 and 1, the organism is intersex (sterile).
If Drosophila has 1 X-chromosome and 4 autosomal chromosomes (A), what is the sex?
Sex Index Ratio = 1 / (4/2) = 0.5. Since it equals 0.5, the organism is male.
If Drosophila has 3 X-chromosomes and 6 autosomal chromosomes (A), what is the sex?
Sex Index Ratio = 3 / (6/2) = 1. Since it equals 1, the organism is female.
If Drosophila has 1 X-chromosome and 6 autosomal chromosomes (A), what is the sex?
Sex Index Ratio = 1 / (6/2) = 0.33. Since it is less than 0.5, the organism is a Super Male / Meta Male.